Sorry, but there’s no defense for the Chromebook Pixel

I had originally decided not to write about how ridiculous Google’s (GOOG) Chromebook Pixel pricing was on Thursday because I figured it was so self-evident that I’d just be repeating what everyone else was already saying. But today I’ve found two contrarian pieces, one from Quartz and one from ZDNet, that make the case that the Chromebook Pixel actually is a brilliant move on Google’s part even if nobody actually ends up buying it. While both pieces do their best to paint a happy picture of the Chromebook Pixel, they both neglect to mention that Google’s strategy with the Pixel seems to fly in the face of everything it’s been trying to accomplish not only with Chromebooks, but with consumer electronics as a whole.

[More from BGR: iPhone found to be 300% more reliable than Samsung smartphones]

Before I go any further, let me say that I’ve long been a fan of Google’s approach to consumer electronics. I like the fact that the company not only opened up the smartphone market to several new manufacturers with its open-source Android platform, but that it also set the bar for low-cost Android tablets with the Nexus 7, which showed that inexpensive Android tablets don’t have to feel cheap. And until this week, I was a big fan of the Chromebook concept: There’s something very appealing about a bare-bones $ 250 laptop that relies on the cloud to store and deliver data and that comes free of the bloatware that has long plagued many Windows laptops.

[More from BGR: Leaked cases may reveal Galaxy S IV design]

All of which makes Google’s strategy with the Chromebook Pixel that much more baffling.

The whole point of Chromebooks is that they’re cheap laptop substitutes for people who just need a computer capable of surfing the web and not much else. Why would anyone pay $ 1,300 or more for a Chromebook that doesn’t differ much more functionality-wise from a Chromebook that costs $ 1,000 less?

As Quartz’s Christopher Mims acknowledges, the Chromebook Pixel’s “only tool” is “a web browser, through which you do all your work using web-based software, with all your files stored in the cloud.” In other words, it’s like all the other Chromebooks except it has a top-notch display and a faster processor, two things that aren’t all that necessary to perform the tasks that most people will use Chromebooks for.

In fact, the Chrome Pixel’s value proposition is so flat-out absurd that it has given me a whole new appreciation for personal computers, warts and all. Because when I’m editing a short movie for a presentation or playing Skyrim or basically doing anything that’s more sophisticated than surfing the web and sending email, I need a PC. And if I’m going to spend $ 1,300 on a computer, I can find things that deliver a lot more value than a web browser with a pretty screen.

This article was originally published on BGR.com

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From Homeless in the Congo to the Oscars Red Carpet: The Story You Must Read Before Tomorrow

Stylewatch
Style News Now

02/23/2013 at 05:40 PM ET

Courtesy Rachel Mwanza

One of the best stories from this year’s Oscars ceremony isn’t taking place on screen, but rather on the red carpet.

Rachel Mwanza, the 16-year-old star of the Best Foreign Language Film nominee War Witch, will be joining her fellow nominees in L.A. after obtaining a visa from the war-torn Democratic Republic of the Congo just days before the Oscars.

The young actress was “discovered” by the War Witch team from a documentary called Kinshasa Kids, which portrayed the life of Mwanza and other children living on the streets in the Congo.

Since being cast in the film, in which she plays a child kidnapped and enslaved to a life of guerilla warfare, her life has changed dramatically — from having a home and education paid for to winning a best actress award at the Berlin Film Festival.

And since her flight arrived late Friday night, she needed a red carpet-worthy dress quickly, which is where Rent the Runway stepped in.

The designer rental service rushed Mwanza several dresses to wear to the Independent Spirit Awards Saturday, from which she chose Kate Spade New York’s “Tiebreaker” style, adding Chamak by Priya Kakkar bangles and a Judith Leiber clutch.

“I’m so excited to be in Los Angeles. I’ve never seen the ocean before!” Mwanza tells PEOPLE through a translator. “I’m tired from my long trip, but way too excited to rest!”

She shared exclusive shots with PEOPLE (above) of her trying-on process, including shots of her caretaker “Mama” helping her zip into her final dress, and the many jewels she was sent to choose from.

And it didn’t take much to get Mwanza ready for her high-profile debut: “I’m going to work it on the red carpet,” she says. “I’ve been practicing my poses!”

The one disappointment from her trip so far? No sightings of a certain superstar. “Beyoncé is my favorite in the whole world. Why is she not here?!” Mwanza jokes.

Below, see a shot of Mwanza and her War Witch producers Marie-Claude Poulin and Pierre Even at the Independent Spirit Awards, and be sure to watch her film, which will be On Demand beginning Tuesday and in select theaters March 1.

And keep an eye out for her at the Oscars Sunday night, where she’ll be wearing a top-secret dress made for her by an African designer. Can’t wait to see her poses!

Courtesy Rachel Mwanza

–Alex Apatoff

PHOTOS: SEE MORE OSCARS STYLE HERE!

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FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

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Investors face another Washington deadline

NEW YORK (Reuters) - Investors face another Washington-imposed deadline on government spending cuts next week, but it's not generating the same level of fear as two months ago when the "fiscal cliff" loomed large.

Investors in sectors most likely to be affected by the cuts, like defense, seem untroubled that the budget talks could send stocks tumbling.

Talks on the U.S. budget crisis began again this week leading up to the March 1 deadline for the so-called sequestration when $85 billion in automatic federal spending cuts are scheduled to take effect.

"It's at this point a political hot button in Washington but a very low level investor concern," said Fred Dickson, chief market strategist at D.A. Davidson & Co. in Lake Oswego, Oregon. The fight pits President Barack Obama and fellow Democrats against congressional Republicans.

Stocks rallied in early January after a compromise temporarily avoided the fiscal cliff, and the Standard & Poor's 500 index <.spx> has risen 6.3 percent since the start of the year.

But the benchmark index lost steam this week, posting its first week of losses since the start of the year. Minutes on Wednesday from the last Federal Reserve meeting, which suggested the central bank may slow or stop its stimulus policy sooner than expected, provided the catalyst.

National elections in Italy on Sunday and Monday could also add to investor concern. Most investors expect a government headed by Pier Luigi Bersani to win and continue with reforms to tackle Italy's debt problems. However, a resurgence by former leader Silvio Berlusconi has raised doubts.

"Europe has been in the last six months less of a topic for the stock market, but the problems haven't gone away. This may bring back investor attention to that," said Kim Forrest, senior equity research analyst at Fort Pitt Capital Group in Pittsburgh.

OPTIONS BULLS TARGET GAINS

The spending cuts, if they go ahead, could hit the defense industry particularly hard.

Yet in the options market, bulls were targeting gains in Lockheed Martin Corp , the Pentagon's biggest supplier.

Calls on the stock far outpaced puts, suggesting that many investors anticipate the stock to move higher. Overall options volume on the stock was 2.8 times the daily average with 17,000 calls and 3,360 puts traded, according to options analytics firm Trade Alert.

"The upside call buying in Lockheed solidifies the idea that option investors are not pricing in a lot of downside risk in most defense stocks from the likely impact of sequestration," said Jared Woodard, a founder of research and advisory firm condoroptions.com in Forest, Virginia.

The stock ended up 0.6 percent at $88.12 on Friday.

If lawmakers fail to reach an agreement on reducing the U.S. budget deficit in the next few days, a sequester would include significant cuts in defense spending. Companies such as General Dynamics Corp and Smith & Wesson Holding Corp could be affected.

General Dynamics Corp shares rose 1.2 percent to $67.32 and Smith & Wesson added 4.6 percent to $9.18 on Friday.

EYES ON GDP DATA, APPLE

The latest data on fourth-quarter U.S. gross domestic product is expected on Thursday, and some analysts predict an upward revision following trade data that showed America's deficit shrank in December to its narrowest in nearly three years.

U.S. GDP unexpectedly contracted in the fourth quarter, according to an earlier government estimate, but analysts said there was no reason for panic, given that consumer spending and business investment picked up.

Investors will be looking for any hints of changes in the Fed's policy of monetary easing when Fed Chairman Ben Bernake speaks before congressional committees on Tuesday and Wednesday.

Shares of Apple will be watched closely next week when the company's annual stockholders' meeting is held.

On Friday, a U.S. judge handed outspoken hedge fund manager David Einhorn a victory in his battle with the iPhone maker, blocking the company from moving forward with a shareholder vote on a controversial proposal to limit the company's ability to issue preferred stock.

(Additional reporting by Doris Frankel; Editing by Kenneth Barry)

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Papal Conclave Accompanied by Reports of Scandals and Intrigue

Osservatore Romano/Reuters

Pope Benedict XVI, right, spoke to cardinals at the Vatican on Saturday.

VATICAN CITY — As cardinals from around the world begin arriving in Rome for a conclave to elect a successor to Pope Benedict XVI, new shadows have fallen over the delicate transition, which the Vatican fears might influence the vote and with it the direction of the Roman Catholic Church.

In recent days, often speculative reports in the Italian news media — some even alleging gay sex scandals in the Vatican, others focusing on particular cardinals stung by the child sex abuse crisis — have dominated headlines, suggesting fierce internal struggles as prelates scramble to consolidate power and attack enemies in the dying days of a troubled papacy.

The reports, which the Vatican has vehemently denied, touch on some of the most vexing issues of Benedict’s reign, including the child sex abuse crisis and international criticisms of the Vatican Bank’s opaque record-keeping. The recent explosion of bad press — which some Vatican experts say is fed by carefully orchestrated leaks meant to weaken some papal contenders — also speak to Benedict’s own difficulties governing, which analysts say he is trying to address, albeit belatedly, with several high-profile personnel changes.

The drumbeat of scandal has reached such a fever pitch that on Saturday, the Vatican Secretariat of State issued a rare pointed rebuke, calling it “deplorable” that ahead of the conclave there was “a widespread distribution of often unverified, unverifiable or completely false news stories, that cause serious damage to persons and institutions.”

The Vatican compared the news reports to past attempts by foreign states to exert pressure on the papal election, saying the latest efforts to skew the choice of the next pope by trying to shape public opinion were “based on judgments that do not typically capture the spiritual aspect of the moment that the Church is living.”

Benedict had hoped to address at least one scandal with the Feb. 15 appointment of a new head of the Vatican Bank. It is less clear why he reassigned a powerful Vatican diplomatic official to a posting outside Rome, though experts say it diminishes the official’s role in helping steer Vatican policy.

On Feb. 11, Benedict made history by announcing that he would step down by month’s end. He said he was worn down by age and was resigning “in full liberty and for the good of the Church.” The volley of news reports since appeared to underscore the backbiting in the Vatican that Benedict was unable to control, and provided a hint of why he might have decided that someone younger and stronger should lead the church.

At the conclusion of the Vatican’s Lenten spiritual retreat, Cardinal Gianfranco Ravasi, the director of the Pontifical Council for Culture and a papal contender, spoke darkly of the “divisions, dissent, careerism, jealousies” that he said plagued the Vatican hierarchy.

The recent spate of news reports were linked to an earlier scandal in which the pope’s butler stole confidential documents that was considered one of the gravest security breaches in the modern history of the church.

Last week, largely unsourced articles in the center-left daily La Repubblica and the center-right weekly Panorama reported that three cardinals whom Benedict had asked last summer to investigate the leaking of the documents, known as the “VatiLeaks” scandal, had found evidence of Vatican officials who had been put in compromising positions.

The newspapers reported that, after interviewing dozens of people inside and outside the Vatican, the cardinals produced a hefty dossier. “The report is explicit. Some high prelates are subject to ‘external influence’ — we would call it blackmail — by nonchurch men to whom they are bound by ‘worldly’ ties,” La Repubblica wrote.

Vatican experts speculated that prelates eager to undermine opponents during the conclave were behind the leaks to the news media over the last week.

“The conclave is a mechanism that serves to create a dynasty in a monarchy without children, so it’s a complicated operation,” said Alberto Melloni, the director of the John XXIII Center in Bologna and the author of a book on conclaves.

This article has been revised to reflect the following correction:

Correction: February 23, 2013

An earlier version of this article misspelled the last name of a cardinal. His name is Roger M. Mahony, not Roger M. Mahoney.

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The end of unlimited BBM could erode BlackBerry’s standing in emerging markets

South Africa has been one of BlackBerry’s (BBRY) key markets globally and the Canadian vendor has held more than 50% of the smartphone market there for years. As the BlackBerry Z10 now rolls out in South Africa, the country will be a key testing ground for a potentially controversial development. Local mobile operators will no longer offer unlimited BlackBerry Messenger service after May 31st, just three months after the Z10 debuts in South Africa.

[More from BGR: Sorry, but there’s no defense for the Chromebook Pixel]

This is perfectly understandable, because the new version of BBM offers advanced IP-based features such as voice and video sharing, which are likely to turn into data hogs. The unlimited internet access that has been a popular part of BlackBerry package deals in emerging markets has fostered heavy data volume growth. It is now being phased out by South African carriers. Things like BBM Voice and BBM Screen Sharing are completely excluded from Vodacom’s Unlimited BBM offer and file-sharing is capped.

[More from BGR: iPhone found to be 300% more reliable than Samsung smartphones]

The decision of MTN and Vodacom to discontinue unlimited BBM service has already triggered some angry responses in South Africa. Unlimited BBM has a unique role in emerging markets, where consumers often have strictly limited or no landline email access. It has become a pivotal middle-class electronic communications channel from South Africa to Nigeria to Indonesia to Malaysia. The big question now is how the revamp of the BBM service will be perceived in these markets.

Will all operators simply phase out unlimited BBM? And how will they price pieces like video and voice? A lot is now riding how BlackBerry frames the transition and how well it communicates the pricing structure changes to users.

Right now, the South African tech media is saying that “unlimited BBM will end in May,” which is not a good framing for the company. New BBM features like voice and video will be of limited benefit to BlackBerry if they are perceived to be costly extras instead of integral parts of the BBM service. The situation is particularly volatile because IP-based, cross-platform messaging services like WhatsApp and 2Go have made major gains in Africa over the past year.

This article was originally published on BGR.com

Wireless News Headlines – Yahoo! News

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The Hunger Games: Katniss & Peeta's Victory Tour Look Revealed

02/22/2013 at 06:00 PM EST

They survived the Hunger Games – but will they survive the Victory Tour?

Sporting bridal-like attire, Katniss (Jennifer Lawrence) and Peeta (Josh Hutcherson) pose for a promotional poster for the Victory Tour – which – in the Hunger Games universe – is when the victor of the annual Hunger Games tournament visits each of the fictional Panem's districts.

As true Hunger Games fans know, there is usually only one victor – but Katniss and Peeta rebelled against the Capitol in the first movie, originally opting for joint suicide instead of murder.

The softer look is a deliberate statement, meant to continue the charade that Katniss and Peeta were blinded by love when they rebelled against the rules in the arena.

The second film, Catching Fire, hits theaters Nov. 22.

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FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

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Wall Street rebounds on HP results, Fed officials' views

NEW YORK (Reuters) - U.S. stocks rose on Friday as Dow component Hewlett-Packard surged on strong results and comments from Fed officials allayed fears that the central bank would curtail its stimulus measures.

Federal Reserve Chairman Ben Bernanke downplayed worries that the Fed has fueled asset bubbles that could hurt the economy in a private meeting with bond dealers and investors earlier this month, Bloomberg reported on Friday.

Bernanke's view helped ease fears that the central bank may end its easy money policies. Minutes from the Federal Reserve's January meeting hit markets on Wednesday as investors interpreted divergent opinions on the benefit of stimulus as a sign the measures may be halted sooner than thought.

"They are in uncharted territory with divergent views," said Jack Ablin, chief investment officer at BMO Private Bank in Chicago. "I could see some pretty heated opinions on what the ultimate outcome is, so I do believe there is dissension."

Hewlett-Packard Co shares jumped more than 12 percent and gave one of the biggest boosts to both the Dow and the S&P 500 after the personal computer maker's quarterly revenue and forecasts beat expectations. Hewlett-Packard's stock rose to $19.20 at the close, up 12.3 percent for the day.

The Dow Jones industrial average <.dji> gained 119.95 points, or 0.86 percent, to 14,000.57 at the close. The Standard & Poor's 500 Index <.spx> rose 13.18 points, or 0.88 percent, to 1,515.60. The Nasdaq Composite Index <.ixic> added 30.33 points, or 0.97 percent, to end at 3,161.82.

With Bernanke's reported comments much on their minds in Friday's session, investors will want the Fed chairman to reiterate his remarks publicly when he speaks before the Senate Banking Committee on Tuesday. That would echo comments made by two top Fed officials on Friday.

Boston Fed President Eric Rosengren and Fed Governor Jerome Powell both defended the U.S. central bank's asset-buying program, arguing that the policy helps the U.S. economy.

The S&P 500 shed 1.9 percent over the previous two sessions, its worst two-day drop since early November, following the release of the Fed's minutes on Wednesday. The selloff marked the end of seven back-to-back weeks of gains for stocks.

For the week, the S&P 500 slipped 0.3 percent and the Nasdaq lost nearly 1 percent. Only the Dow ended the week with a gain - up just 0.1 percent.

HP's results come near the end of a relatively strong earnings season in which 70 percent of S&P 500 companies beat analysts' expectations, compared with a 62 percent average since 1994 and 65 percent over the past four quarters, according to Thomson Reuters data.

"Overall, the earnings supports were better than expected in this cycle," said Peter Jankovskis, co-chief investment officer at OakBrook Investments LLC in Lisle, Illinois. "We may see the market rising during the month of March."

Fourth-quarter earnings for S&P 500 companies are estimated to have risen 6 percent, according to the data, above a 1.9 percent forecast at the start of the earnings season.

But with only a handful of companies left to report earnings, investors are looking ahead to the possibility of hefty automatic budget cuts that could happen on March 1.

A large option investor appeared to be adjusting a bearish view on the SPDR S&P 500 Trust fund while locking in previously established gains, in a possible hedge ahead of the automatic budget cuts that are set to take effect at the beginning of next month. The play involved weekly puts, expiring next Friday.

"An institutional investor appears to be rolling down and increasing in size a defensive hedge timed to match the March 1 deadline for the sequester," said Henry Schwartz, president of options analytics firm Trade Alert.

The trader sold 132,000 $149 to $150 weekly put spreads for 22 cents as shares of the exchange-traded fund had traded near $151.14 on Friday morning. The transaction entailed the sale of $150 weekly puts to buy the $149 weekly puts. In addition, the investor purchased another 42,000 $149 weekly puts, which increases the size of the hedge to 174,000 contracts.

"It is likely this large position protects an existing underlying long position in a portfolio," Schwartz said.

In another political risk factor, Italians go to the polls this weekend in an election that could threaten reforms in the indebted country. Silvio Berlusconi's resurgence has thrown the vote wide open, with deep uncertainty over whether the poll can produce the strong government the country needs.

Inconclusive Greek elections last year sparked a protracted selloff and a period of uncertainty in markets.

In the tech sector, Marvell Technology Group Ltd forecast results this quarter that were largely above analysts' expectations. Marvell gained market share in the hard-disk drive and flash-storage businesses. The stock rose 4.4 percent to $9.89.

Texas Instruments Inc raised its dividend by a third and boosted its stock-buyback program, driving its stock up 5.2 percent to $34.18.

The PHLX semiconductor index <.sox> gained 2.1 percent.

"Dividends growing are another way the market's level is justified, if not especially attractive at these levels," said Rex Macey, chief investment officer of Wilmington Trust in Atlanta, who manages about $20 billion in assets.

On the downside, Abercrombie & Fitch dropped 4.5 percent to $46.86 after the youth-oriented clothing retailer reported a drop in fourth-quarter comparable sales, even as its latest quarterly earnings topped estimates.

Insurer American International Group Inc posted fourth-quarter results that beat analysts' expectations. AIG's stock advanced 3.1 percent to $38.45.

About three stocks rose for every one that fell on both the New York Stock Exchange and Nasdaq.

Around 5.8 billion shares changed hands on the New York Stock Exchange, the Nasdaq and NYSE MKT, below the 20-day moving average of around 6.51 billion shares.

(Additional Reporting by Ryan Vlastelica and Doris Frankel; Editing by Kenneth Barry and Jan Paschal)

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In Niger, U.S. Troops Set Up Drone Base

WASHINGTON — Opening a new front in the drone wars against Al Qaeda and its affiliates, President Obama announced on Friday that about 100 American troops had been sent to Niger in West Africa to help set up a new base from which unarmed Predator aircraft would conduct surveillance in the region.

The new drone base, located for now in the capital, Niamey, is an indication of the priority Africa has become in American antiterrorism efforts. The United States military has a limited presence in Africa, with only one permanent base, in Djibouti, more than 3,000 miles from Mali, where insurgents had taken over half the country until repelled by a French-led force.

In a letter to Congress, Mr. Obama said about 40 United States military service members arrived in Niger on Wednesday, bringing the total number of those deployed in the country to about 100 people. A military official said the troops were largely Air Force logistics specialists, intelligence analysts and security officers.

Mr. Obama said the troops, who are armed for self-protection, would support the French-led operation that last month drove the Qaeda and affiliated fighters out of a desert refuge the size of Texas in neighboring Mali.

Niger, one of the poorest countries in the world, signed a status-of-forces agreement last month with the United States that has cleared the way for greater American military involvement in the country and provides legal protection to American troops there.

In an interview last month in Niamey, President Mahamadou Issoufou voiced concern about the spillover of violence and refugees from Mali, as well as growing threats from Boko Haram, an Islamist extremist group to the south, in neighboring Nigeria.

French and African troops have retaken Mali’s northern cities, including Timbuktu, Gao and Kidal, but about 2,000 militants have melted back into desert and mountain hideaways and have begun a small campaign of harassment and terror, dispatching suicide bombers, attacking guard posts, infiltrating liberated cities or ordering attacks by militants hidden among civilians.

“Africa Command has positioned unarmed remotely piloted aircraft in Niger to support a range of regional security missions and engagements with partner nations,” Benjamin Benson, a command spokesman in Stuttgart, Germany, said in an e-mail message on Friday.

Mr. Benson did not say how many aircraft or troops ultimately would be deployed, but other American officials have said the base could eventually have as many as 300 United States military service members and contractors.

For now, American officials said Predator drones would at first fly only unarmed surveillance drones, although they have not ruled out conducting missile strikes at some point if the threat worsens.

American officials would like to move the aircraft eventually to Agadez, a city in northern Niger that is closer to parts of northern Mali where cells of Al Qaeda in the Islamic Maghreb and other militants groups are operating. Gen. Carter F. Ham, the leader of the Pentagon’s Africa Command, visited the base last month as part of discussions with Niger’s leaders on closer counterterrorism cooperation.

The new drone base will join a constellation of small airstrips in recent years on the continent, including one in Ethiopia, for surveillance missions flown by drones or turboprop planes designed to look like civilian aircraft.

A handful of unarmed Predator drones will fill a desperate need for more detailed information on regional threats, including the militants in Mali and the unabated flow of fighters and weapons from Libya. General Ham and intelligence analysts have complained that such information has been sorely lacking.

As the United States increased its presence in Niger, Russia sent a planeload of food, blankets and other aid to Mali on Friday, a day after Foreign Minister Sergey V. Lavrov warned about the spread of terrorism in North Africa, which the Russian government has linked to Western intervention in Libya.

Mr. Lavrov met on Thursday with the United Nations special envoy for the region, Romano Prodi, to discuss the situation in Mali, where Russia has supported the French-led effort to oust Islamist militants. But Russia has also blamed the West for the unrest and singled out the French in particular for arming the rebels who ousted the Libyan leader, Col. Muammar el-Qaddafi.

“Particular concern was expressed about the activity of terrorist organizations in the north, a threat to regional peace and security,” the Russian Foreign Ministry said in a statement after the meeting. “The parties agreed that the uncontrolled proliferation of arms in the region in the wake of the conflict in Libya sets the stage for an escalation of tension throughout the Sahel.” The Sahel is a vast region stretching more than 3,000 miles across Africa, from the Atlantic in the west through Sudan in the east.

In a television interview this month, Mr. Lavrov said, “France is fighting against those in Mali whom it had once armed in Libya against Qaddafi.”

Eric Schmitt reported from Washington, and Scott Sayare from Paris. David M. Herszenhorn contributed reporting from Moscow.

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NZ’s Telecom lowers profit guidance, sees job cuts

WELLINGTON (Reuters) – New Zealand’s Telecom Corp Ltd lowered its earnings guidance for the year and warned of hundreds of job cuts as the country’s biggest telecommunications company struggles to compete on broadband pricing and in its business operations.

The top-10 firm warned that ongoing restructuring would result in more job losses down the line and could see full-year adjusted earnings come in at NZ$ 1.04 billion to NZ$ 1.06 billion, lower than its previous forecast of flat to a low single-digit percentage fall from NZ$ 1.09 billion in 2012.

“It is pretty apparent that it will be well into the hundreds (of staff cuts) over the next few months,” Telecom Chief Executive Officer Simon Moutter told reporters, adding that it would announce details in May.

The job losses would follow roughly 350 cuts to date.

The top-10 firm’s adjusted net profit was NZ$ 162 million, slightly higher than market expectations as growth in its mobile business offset low margins on its broadband price plans, while fixed-line businesses also suffered.

Forecasts had been for profits of NZ$ 157 million, according to a Reuters poll of three analysts.

Profits were significantly down from NZ$ 240 million in 2012, reflecting significant one-off gains made last year from its demerger in late 2011, when it split off its fixed-line network operations into Chorus Ltd.

Telecom offers retail fixed-line and Internet services, using Chorus’s network but sells mobile services using the network infrastructure it retained.

It announced a dividend of 8 cents per share, down from 9 cents last year.

Despite Telecom’s downgraded outlook, its shares rose 1.1 percent to a session high of NZ$ 2.23, on optimism that restructuring will help the firm compete with Vodafone, in the broadband market after it bought Telstraclear’s operations last year.

“There’s some anticipation of the restructuring potential coming through,” said Shane Solly, portfolio manager at Mint Asset Management in Auckland.

But he added that Telecom could face a rocky future, adding, “The restructuring announcement will be very influential in how people consider the company going forward.”

Earlier this week Telecom said it would join Vodafone and Australia’s Telstra to build a submarine cable between New Zealand and Australia, offering increased capacity and speeds.

(Reporting by Naomi Tajitsu; Editing by Kenneth Barry)

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Survivor's Whitney Duncan: From Secret Marriage to Divorce to Engagement!

TV Watch

By Patrick Gomez

02/21/2013 at 06:45 PM EST

Whitney Duncan and Keith Tollefson

Monty Brinton/CBS; Inset: Courtesy Whitney Duncan

Country singer and former Survivor contestant Whitney Duncan is engaged – and this time it's not a secret.

"I'm going to marry this man," Duncan Tweeted on Feb. 14 shortly after announcing her engagement to her fellow Survivor tribemate Keith Tollefson.

Duncan, 28, was secretly married when she met and fell for Tollefson, 27, on Survivor: South Pacific in the summer of 2011 but now the tribemates are headed down the aisle.

"He did good," Duncan wrote on Facebook along with a photo of her sparkling engagement ring of interlocking circles in a complex pattern.

Whitney Duncan and Keith Tollefson

Courtesy Whitney Duncan

The "Skinny Dippin' " singer portrayed herself as single on the 23rd season of the CBS reality show, but she had actually been married to Donny Fallgatter, lead singer for the band KingBilly, since August 2010.

Fallgatter and Duncan had kept their marriage a secret from even friends and family until Duncan confessed her feelings for Tollefson to Fallgatter during a phone call made just before she returned from filming Survivor, a source close to the couple told PEOPLE in 2011.

The country couple's divorce proceedings were complete in November 2011 and now Duncan and Tollefson – a self-described environmentalist – are happily celebrating their impending nuptials.

"Thanks to everyone for the best wishes on mine and @whitneyduncan's engagement," Tollefson tweeted. "I know real original proposing on Valentines day ha."

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Flu shot doing poor job of protecting older people

ATLANTA (AP) — It turns out this year's flu shot is doing a startlingly dismal job of protecting older people, the most vulnerable age group.

The vaccine is proving only 9 percent effective in those 65 and older against the harsh strain of the flu that is predominant this season, the Centers for Disease Control and Prevention said Thursday.

Health officials are baffled as to why this is so. But the findings help explain why so many older people have been hospitalized with the flu this year.

Despite the findings, the CDC stood by its recommendation that everyone over 6 months get flu shots, the elderly included, because some protection is better than none, and because those who are vaccinated and still get sick may suffer less severe symptoms.

"Year in and year out, the vaccine is the best protection we have," said CDC flu expert Dr. Joseph Bresee.

Overall, across the age groups studied, the vaccine's effectiveness was found to be a moderate 56 percent, which means those who got a shot have a 56 percent lower chance of winding up at the doctor with the flu. That is somewhat worse than what has been seen in other years.

For those 65 and older, the vaccine was only 27 percent effective against the three strains it is designed to protect against, the worst level in about a decade. It did a particularly poor job against the tough strain that is causing more than three-quarters of the illnesses this year.

It is well known that flu vaccine tends to protect younger people better than older ones. Elderly people have weaker immune systems that don't respond as well to flu shots, and they are more vulnerable to the illness and its complications, including pneumonia.

But health officials said they don't know why this year's vaccine did so poorly in that age group.

One theory, as yet unproven, is that older people's immune systems were accustomed to strains from the last two years and had more trouble switching gears to handle this year's different, harsh strain.

The preliminary data for senior citizens is less than definitive. It is based on fewer than 300 people scattered among five states.

But it will no doubt surprise many people that the effectiveness is that low, said Michael Osterholm, a University of Minnesota infectious-disease expert who has tried to draw attention to the need for a more effective flu vaccine.

Among infectious diseases, flu is considered one of the nation's leading killers. On average, about 24,000 Americans die each flu season, according to the CDC.

This flu season started in early December, a month earlier than usual, and peaked by the end of year. Hospitalization rates for people 65 and older have been some of the highest in a decade, at 146 per 100,000 people.

Flu viruses tend to mutate more quickly than others, so a new vaccine is formulated each year to target the strains expected to be the major threats. CDC officials have said that in formulating this year's vaccine, scientists accurately anticipated the strains that are circulating this season.

Because of the guesswork involved, scientists tend to set a lower bar for flu vaccine. While childhood vaccines against diseases like measles are expected to be 90 or 95 percent effective, a flu vaccine that's 60 to 70 percent effective in the U.S. is considered pretty good. By that standard, this year's vaccine is OK.

For senior citizens, a flu vaccine is considered pretty good if it's in the 30 to 40 percent range, said Dr. Arnold Monto, a University of Michigan flu expert.

A high-dose version of the flu shot was recently made available for those 65 and older, but the new study was too small to show whether that has made a difference.

The CDC estimates are based on about 2,700 people who got sick in December and January. The researchers traced back to see who had gotten shots and who hadn't. An earlier, smaller study put the vaccine's overall effectiveness at 62 percent, but other factors that might have influenced that figure weren't taken into account.

The CDC's Bresee said there is a danger in providing preliminary results because it may result in people doubting — or skipping — flu shots. But the figures were released to warn older people who got shots that they may still get sick and shouldn't ignore any serious flu-like symptoms, he said.

___

Online:

CDC report: http://www.cdc.gov/mmwr

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Wall Street ends lower on growth worries

NEW YORK (Reuters) - U.S. stocks fell for a second straight day on Thursday and the S&P 500 posted its worst two-day loss since November after reports cast doubt over the health of the U.S. and euro-zone economies.

But a late-day rally helped stocks erase some of their losses with most of the pullback concentrated in the technology- heavy Nasdaq. The move suggested investors were still willing to buy on dips even after the sharp losses in the last session.

In Europe, business activity indexes dealt a blow to hopes that the euro zone might emerge from recession soon, showing the downturn across the region's businesses unexpectedly grew worse this month.

"The PMI numbers out of Europe were really a blow to the market," said Jack De Gan, chief investment officer at Harbor Advisory in Portsmouth, New Hampshire. "The market was expecting signs that recovery is still there, but the numbers just highlighted that the euro-zone problem is still persistent."

U.S. initial claims for unemployment benefits rose more than expected last week while the Federal Reserve Bank of Philadelphia said its index of business conditions in the U.S. mid-Atlantic region fell in February to the lowest in eight months.

Gains in Wal-Mart Stores Inc shares helped cushion the Dow. The shares gained 1.5 percent to $70.26 after the world's largest retailer reported earnings that beat expectations, though early February sales were sluggish.

The Dow Jones industrial average <.dji> fell 46.92 points, or 0.34 percent, to 13,880.62 at the close. The Standard & Poor's 500 Index <.spx> lost 9.53 points, or 0.63 percent, to 1,502.42. The Nasdaq Composite Index <.ixic> dropped 32.92 points, or 1.04 percent, to close at 3,131.49.

The two-day decline marked the U.S. stock market's first sustained pullback this year. The Standard & Poor's 500 has fallen 1.8 percent over the period and just managed to hold the 1,500 level on Thursday. Still, the index is up 5.3 percent so far this year.

The abrupt reversal in markets, which started on Wednesday after minutes from the Federal Reserve's January meeting suggested stimulus measures may end earlier than thought, looks set to halt a seven-week winning streak for stocks that had lifted the Dow and the S&P 500 close to all-time highs.

Wall Street will soon face another test with the upcoming debate in Washington over the automatic across-the-board spending cuts put in place as part of a larger congressional budget fight. Those cuts, set to kick in on March 1 unless lawmakers agree on an alternative, could depress the economy.

Semiconductor stocks ranked among the weakest of the day, pressuring the Nasdaq as the Philadelphia Semiconductor Index <.sox> fell 1.8 percent. Intel Corp fell 2.3 percent to $20.25 while Advanced Micro Devices lost 3.7 percent to $2.60 as the S&P 500's biggest percentage decliner.

The Dow also got a helping hand from personal computer maker Hewlett-Packard Co , which rose 2.3 percent to end the regular session at $17.10. The company was scheduled due to report first-quarter results after the closing bell.

Shares of Boeing Co rose 1.6 percent to $76.01 as a senior executive was set to meet with the head of the U.S. Federal Aviation Administration on Friday and present a series of measures to prevent battery failures that grounded its 787 Dreamliner fleet, according to a source familiar with the plans.

In other company news, shares of supermarket operator Safeway Inc jumped 14.1 percent to $22.97 after the company reported earnings that beat expectations.

Shares of VeriFone Systems Inc tumbled nearly 43 percent to $18.24 after the credit-card swipe machine maker forecast first- and second-quarter profits well below expectations.

Of the 427 companies in the S&P 500 that have reported results so far, 69.3 percent have exceeded analysts' expectations, compared with a 62 percent average since 1994 and 65 percent over the past four quarters, according to Thomson Reuters data through Thursday morning.

Fourth-quarter earnings for S&P 500 companies are estimated to have risen 5.9 percent, according to the data, above a 1.9 percent forecast at the start of the earnings season.

Berry Petroleum Co jumped 19.3 percent to $46.02 after oil and gas producer Linn Energy LLC said it would buy the company in an all-stock deal valued at $4.3 billion, including debt. Linn Energy shares advanced 2.8 percent to $37.68.

About two stocks fell for everyone that rose on the New York Stock Exchange and Nasdaq. About 7.64 billion shares changed hands on the New York Stock Exchange, the Nasdaq and NYSE MKT, well above the 20-day moving average of around 6.6 billion shares.

(Editing by Jan Paschal)

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15 G.O.P. Senators Ask Obama to Withdraw Hagel Nomination

WASHINGTON — A group of 15 Republican senators insisted on Thursday that President Obama withdraw the nomination of Chuck Hagel to be defense secretary, the latest move in a contentious battle to block the confirmation of their former colleague.

But even as Republican senators tried to throw up another obstacle, Senate Democrats said they were pushing ahead with plans to hold a final up-or-down vote on the nomination no later than Wednesday.

Should that vote proceed as planned, Mr. Hagel’s confirmation appears assured. Several Republicans have said that they intend to drop their attempts to filibuster the nomination.

But given how deeply divided Mr. Hagel’s nomination has left the Senate, the outlook in the immediate term is murky.

Many Republicans, like the 15 who wrote to the president on Thursday, signaled that they would not let the issue die quietly. And those who have said that they would ultimately not support a filibuster, like Deb Fischer of Nebraska and Richard Shelby of Alabama, were choosing their words carefully.

Saying that Mr. Hagel’s confirmation would be “unprecedented” because of near-unanimous opposition from Republicans, the group of 15 senators urged Mr. Obama to pick another candidate.

“Over the last half-century, no secretary of defense has been confirmed and taken office with more than three senators voting against him,” they wrote. “The occupant of this critical office should be someone whose candidacy is neither controversial or divisive.”

Signing the letter were John Cornyn of Texas, the No. 2 Senate Republican; Lindsey Graham and Tim Scott of South Carolina; Roger Wicker of Mississippi; David Vitter of Louisiana; Ted Cruz of Texas; Mike Lee of Utah; Patrick J. Toomey of Pennsylvania; Marco Rubio of Florida; Dan Coats of Indiana; Ron Johnson of Wisconsin; James E. Risch of Idaho; John Barrasso of Wyoming; and Tom Coburn and James Inhofe of Oklahoma.

Members of the group cited a litany of objections, including Mr. Hagel’s unimpressive showing at his confirmation hearing, which drew criticism from members of both parties, and what they said was his “dangerous” posture toward dealing with Iran.

The level of derision directed at Mr. Hagel from Republicans has been striking not just because defense secretaries are usually confirmed on a simple up-or-down vote, but also because Mr. Hagel, a Republican, served with many of them in the Senate until 2008.

“Senator Hagel’s performance at his confirmation hearing was deeply concerning, leading to serious doubts about his basic competence to meet the substantial demands of the office,” they said.

Senate Republicans narrowly blocked a vote on Mr. Hagel’s confirmation last week in a filibuster, forcing Democrats to put the matter off until senators return from recess next week.

Republicans have been using the filibuster to prevent final consideration of the nomination by refusing to end debate on it, a procedural step that requires 60 senators to vote in the affirmative.

But some Republicans, including Senator John McCain of Arizona, have since said that they will drop their objections. Mr. McCain was firm, saying on Sunday, “I don’t believe that we should hold up his nomination any further.”

Others, like Mr. Graham, Mr. Shelby and Ms. Fischer, have said that while they do not support a filibuster, they believe that the senators should have ample time to consider their votes, leaving themselves open to voting not to end debate next week.

Only one more Republican “yes” vote would be needed to cut off debate and carry through with a final vote if all the Republicans who voted to end the filibuster last week voted to do so again.

Because Mr. Hagel has the support of Senate Democrats, who control 55 seats, he is likely to clear a final vote.

If Senate Democrats move ahead with a vote and get the 60 votes necessary to end debate, Mr. Hagel could be confirmed as early as Tuesday. But because of procedural rules, any Republican could still delay the vote until Wednesday.

A new voice chimed in on the debate on Thursday. Bob Dole, the former Senate majority leader and, like Mr. Hagel, a decorated veteran, urged his fellow Republicans to put aside their objections.

“Hagel’s wisdom and courage make him uniquely qualified to be secretary of defense and lead the men and women of our armed forces,” Mr. Dole said, adding that he would be “an exceptional leader at an important time.”

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Cuban dissident blogger inflames splits in Brazil’s Congress

BRASILIA (Reuters) – Cold War politics appeared to take over Brazil‘s Congress on Wednesday during a visit by Cuban blogger Yoani Sanchez, with leftists heckling her as a pawn of U.S. imperialism and others praising her for standing up to Cuba‘s communist government.

Sanchez, Cuba’s best-known dissident, has been followed by boisterous sympathizers of the Cuban government since she arrived in Brazil on Monday on her first trip abroad since receiving a passport to leave the Caribbean island.

After the screening of a documentary about Cuba that she was due to attend in northeastern Brazil was disrupted by demonstrators, Brazilian opposition politicians invited Sanchez to the capital Brasilia for a showing of the documentary in Congress.

But her visit ended up exposing entrenched political divides in Brazil reminiscent of the Cold War, with those on the left hailing Cuba as a victim of U.S. aggression against communism while others praised Sanchez for fighting against political repression on the island.

“Mercenary, go to Disney,” shouted those opposed to her visit, repeating the Cuban government’s view that all dissidents on the island are on the payroll of its ideological archenemy, the United States.

“Down with the dictatorship,” yelled sympathizers who welcomed the blogger.

Sanchez, 37, was shielded from the protesters by congressional and Senate leaders of Brazil’s main opposition party, the PSDB, led by feisty Senator Alvaro Dias.

Dias has called on members of the ruling Workers’ Party and the Cuban ambassador to explain to Congress media allegations that the Cuban embassy in Brasilia has spied on Sanchez and distributed a “dossier” on the blogger as part of carefully orchestrated smear campaign.

An unperturbed Sanchez visited a committee room to see parts of the documentary, titled “Cuba-Honduras Connection,” that she had not been able to attend on Monday in Bahia state. The screening of the film, in which she is featured, was the main reason for her trip to Brazil in the first place.

“I dream of the day when we Cubans can express ourselves freely, and have a legislature where all opinions can be heard,” Sanchez told reporters. “The legislature of my country has a sad record. It has never said ‘no’ to any law proposed by the government.”

Sanchez’s visit touched a political nerve in Brazil, where the left-leaning government of President Dilma Rousseff is often criticized for not taking a more critical stance against Cuba’s one-party system and the repression of political dissent there. ID:nL1N0BJ08I]

Sanchez has won several international prizes for blogging about life in Cuba but has been unable to collect them until now. She began a whirlwind 80-day international tour on Sunday after she was granted a passport two weeks ago under Cuba’s sweeping immigration reform that went into effect this year.

In Brazil, Sanchez praised recent reforms undertaken by Cuban President Raul Castro but said they were too little.

(Reporting by Maria Carolina Marcello; Writing by Anthony Boadle)

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Oscar Preview: Les Mis, Chicago Casts to Sing & Dance

By Stephen M. Silverman

02/20/2013 at 07:00 PM EST

From left: Hugh Jackman and Anne Hathaway, in Les Misérables, and Catherine Zeta Jones, in Chicago

Universal (2); Miramax

Strike up the band, for Sunday night's Oscars promise to be very musical.

In the most detailed preview yet of what is to be expected – and what isn't – the 85th annual Academy Awards producers Craig Zadan and Neil Meron tell Deadline.com that their special tribute to the resurgence of movie musicals in the past decade will star Les Misérables nominees Hugh Jackman and Anne Hathaway with costars Russell Crowe, Eddie Redmayne, Aaron Tevit, Samantha Barks, and Helena Bonham Carter; Dreamgirls Oscar winner Jennifer Hudson; and Chicago winner Catherine Zeta-Jones.

"What we don't want to do is play it safe," says Zadan about the show in general, admitting – repeatedly – that the job of producing it is "enormous."

So is the Oscar night orchestra: 60 pieces. Accompanying all those instruments will be:

• The previously announced Justin Timberlake, as well as Barbra Streisand, who's only sung on the show once before in her 5½-decade career (and that was 36 years ago)

• Golden Globe song winner Adele ("Skyfall" is up for Best Song) and "Goldfinger" diva Shirley Bassey, an Oscar newbie, who'll appear as part of the James Bond 50th anniversary tribute

• And the evening's host, Seth MacFarlane, who's been known to break into song on more than one occasion – such as when he hosted SNL.

Other reveals:

• "It's not going to be three hours but we will try to get it close to that," says Zadan. (There are 24 categories to recognize.)

• Six college filmmaking students will serve as Oscar presenters after winning a contest to be on the show.

• The 007 tribute will not feature a reunion of Sean Connery, George Lazenby, Roger Moore, Timothy Dalton, Pierce Brosnan and Daniel Craig.

• MacFarlane's opening monologue is "clever and sort of unique … like a throwback to the days of Bob Hope and Johnny Carson," says Zadan.

• Streisand's number is being kept a secret, "but we love the speculation," says Meron.

The 85th annual Academy Awards will air live on Sunday, Feb. 24, on ABC from the Dolby Theatre in Hollywood.

Justin Timberlake and Barbra Streisand

Justin Lane / Landov; Walter McBride / Retna

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Scientists use 3-D printing to help grow an ear

WASHINGTON (AP) — Printing out body parts? Cornell University researchers showed it's possible by creating a replacement ear using a 3-D printer and injections of living cells.

The work reported Wednesday is a first step toward one day growing customized new ears for children born with malformed ones, or people who lose one to accident or disease.

It's part of the hot field of tissue regeneration, trying to regrow all kinds of body parts. Scientists hope using 3-D printing technology might offer a speedier method with more lifelike results.

If it pans out, "this enables us to rapidly customize implants for whoever needs them," said Cornell biomedical engineer Lawrence Bonassar, who co-authored the research published online in the journal PLoS One.

This first-step work crafted a human-shaped ear that grew with cartilage from a cow, easier to obtain than human cartilage, especially the uniquely flexible kind that makes up ears. Study co-author Dr. Jason Spector of Weill Cornell Medical Center is working on the next step — how to cultivate enough of a child's remaining ear cartilage in the lab to grow an entirely new ear that could be implanted in the right spot.

Wednesday's report is "a nice advancement," said Dr. Anthony Atala, director of the Institute for Regenerative Medicine at Wake Forest Baptist Medical Center, who wasn't involved in the new research.

Three-dimensional printers, which gradually layer materials to form shapes, are widely used in manufacturing. For medicine, Atala said the ear work is part of broader research that shows "the technology now is at the point where we can in fact print these 3-dimensional structures and they do become functional over time."

Today, people who need a new ear often turn to prosthetics that require a rod to fasten to the head. For children, doctors sometimes fashion a new ear from the stiffer cartilage surrounding ribs, but it's a big operation. Spector said the end result seldom looks completely natural. Hence the quest to use a patient's own cells to grow a replacement ear.

The Cornell team started with a 3-D camera that rapidly rotates around a child's head for a picture of the existing ear to match. It beams the ear's geometry into a computer, without the mess of a traditional mold or the radiation if CT scans were used to measure ear anatomy.

"Kids aren't afraid of it," said Bonassar, who used his then-5-year-old twin daughters' healthy ears as models.

From that image, the 3-D printer produced a soft mold of the ear. Bonassar injected it with a special collagen gel that's full of cow cells that produce cartilage — forming a scaffolding. Over the next few weeks, cartilage grew to replace the collagen. At three months, it appeared to be a flexible and workable outer ear, the study concluded.

Now Bonassar's team can do the process even faster by using the living cells in that collagen gel as the printer's "ink." The 3-D technology directly layers the gel into just the right ear shape for cartilage to cover, without having to make a mold first.

The next step is to use a patient's own cells in the 3-D printing process. Spector, a reconstructive surgeon, is focusing on children born without a fully developed external ear, a condition called microtia. They have some ear cartilage-producing cells in that tissue, just not enough. So he's experimenting with ways to boost those cells in the lab, "so we can grow enough of them from that patient to make an ear," he explained.

That hurdle aside, cartilage may be the tissue most amenable to growing with the help of 3-D printing technology, he said. That's because cartilage doesn't need blood vessels growing inside it to survive.

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Wall Street ends down sharply after Fed minutes

(Reuters) - And the Oscar for best pickup line in a movie goes to - Audrey Hepburn in the romantic thriller, "Charade." That's according to the results from women polled by the U.K.-based dating site Badoo.com and released on Wednesday before the Academy Awards on Sunday. "I don't bite you know ... unless it's called for," Hepburn told Cary Grant in the 1963 release, and, 50 years later, women still chose it first. Men, however, had different ideas. They favored this Bette Davis line from the 1932 movie, "The Cabin in the Cotton," - "I'd love to kiss you, but I just washed my hair. ...

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The Lede: Palestinian Filmmaker Describes Detention at Los Angeles Airport

The trailer for “5 Broken Cameras,” Emad Burnat’s autobiographical film on life in the West Bank.

The Palestinian filmmaker Emad Burnat, who had a hard time convincing immigration officers at Los Angeles International Airport on Tuesday that his invitation to this weekend’s Academy Awards was real, described his brief detention in a statement on Wednesday.

Last night, on my way from Turkey to Los Angeles, my family and I were held at U.S. immigration for about an hour and questioned about the purpose of my visit to the United States. Immigration officials asked for proof that I was nominated for an Academy Award for the documentary “5 Broken Cameras,” and they told me that if I couldn’t prove the reason for my visit, my wife Soraya, my son Gibreel and I would be sent back to Turkey on the same day.

After 40 minutes of questions and answers, Gibreel asked me why we were still waiting in that small room. I simply told him the truth: “Maybe we’ll have to go back.” I could see his heart sink. Although this was an unpleasant experience, this is a daily occurrence for Palestinians, every single day, throughout the West Bank. There are more than 500 Israeli checkpoints, roadblocks, and other barriers to movement across our land, and not a single one of us has been spared the experience that my family and I experienced yesterday. Ours was a very minor example of what my people face every day.

As my colleague Jennifer Schuessler reported, Mr. Burnat, who was nominated along with his Israeli co-director Guy Davidi for his autobiographical film about the difficulties of life in the occupied West Bank, was eventually released after a previous winner of the Oscar for best documentary, Michael Moore, managed to get a lawyer for the Academy of Motion Picture Arts and Sciences to intervene.

My blog today on Palestinian Oscar nominee Emad Burnat detained last nite at LAX because he didn’t look Oscar-ish enuff http://t.co/WH81TCjt

— Michael Moore (@MMFlint) 20 Feb 13

In a post on his blog, Mr. Moore explained that he was waiting for the Palestinian filmmaker at a dinner for nominees when he received an urgent appeal for help.

I received an urgent text from Emad, written to me from a holding pen at the Los Angeles International Airport (LAX). Here is what it said, in somewhat broken English: “Urgent – I am in the air port la they need more information why I come here. Invitation or some thing. Can you help they will send us back. If you late, Emad.”

I quickly texted him back and told him that help was on the way. He wrote back to say Immigration and Customs was holding him, his wife, Soraya, and their 8-year old son (and “star” of the movie) Gibreel in a detention room at LAX. He said they would not believe him when he told them he was an Oscar-nominated director on his way to this Sunday’s Oscars and to the events in LA leading up to the ceremony. He is also a Palestinian. And a olive farmer. Apparently that was too much for Homeland Security to wrap its head around.

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Nexus 7 sales soared in 2012, but still fell short of iPad mini and Kindle Fire

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What's Next for Mindy McCready's Two Young Boys?

By Steve Helling

02/19/2013 at 07:00 PM EST

Mindy McCready's apparent suicide on Sunday has left her two young sons in custodial limbo.

The boys – Zander, 6, and Zayne, 10 months – had been in state custody since Feb. 7, when McCready called police to ask for help in making her father and stepmother leave her home. When police arrived, McCready appeared to be intoxicated, according to a Department of Human Services report.

In a subsequent petition, the singer's father, Tim McCready, asked the court to order her to undergo mental health and substance abuse evaluation and treatment, alleging that his daughter, who had recently lost her boyfriend, "hasn't had a bath in a week ... screams about everything ... [is] very verbally abusive to Zander."

After a judge granted the petition, the children were quickly removed and placed into foster care. Although McCready was released from treatment, the boys remained in state custody.

At the time, Zander's father, Billy McKnight, requested custody of his son. "My son needs me." he told PEOPLE on Feb. 8. "I'm married, working and successful. I'm on the right track and proud of it. I've been sober for years. I just want my son."

But McCready's mother and stepfather, Gayle and Michael Inge, also want custody of the children – and authorities seem to agree.

In a proposed order sent to Circuit Judge Lee Harrod, the Department of Human Services proposed that the Inges might be a better fit for the children, claiming that they have "a substantial relationship." The Inges had custody of Zander for much the past few years, during McCready’s rehab and jail stints.

With McCready's death, the judge will have to determine what is in the children's best interest. A custody hearing has been scheduled for April 5.

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Drug overdose deaths up for 11th consecutive year

CHICAGO (AP) — Drug overdose deaths rose for the 11th straight year, federal data show, and most of them were accidents involving addictive painkillers despite growing attention to risks from these medicines.

"The big picture is that this is a big problem that has gotten much worse quickly," said Dr. Thomas Frieden, head of the Centers for Disease Control and Prevention, which gathered and analyzed the data.

In 2010, the CDC reported, there were 38,329 drug overdose deaths nationwide. Medicines, mostly prescription drugs, were involved in nearly 60 percent of overdose deaths that year, overshadowing deaths from illicit narcotics.

The report appears in Tuesday's Journal of the American Medical Association.

It details which drugs were at play in most of the fatalities. As in previous recent years, opioid drugs — which include OxyContin and Vicodin — were the biggest problem, contributing to 3 out of 4 medication overdose deaths.

Frieden said many doctors and patients don't realize how addictive these drugs can be, and that they're too often prescribed for pain that can be managed with less risky drugs.

They're useful for cancer, "but if you've got terrible back pain or terrible migraines," using these addictive drugs can be dangerous, he said.

Medication-related deaths accounted for 22,134 of the drug overdose deaths in 2010.

Anti-anxiety drugs including Valium were among common causes of medication-related deaths, involved in almost 30 percent of them. Among the medication-related deaths, 17 percent were suicides.

The report's data came from death certificates, which aren't always clear on whether a death was a suicide or a tragic attempt at getting high. But it does seem like most serious painkiller overdoses were accidental, said Dr. Rich Zane, chair of emergency medicine at the University of Colorado School of Medicine.

The study's findings are no surprise, he added. "The results are consistent with what we experience" in ERs, he said, adding that the statistics no doubt have gotten worse since 2010.

Some experts believe these deaths will level off. "Right now, there's a general belief that because these are pharmaceutical drugs, they're safer than street drugs like heroin," said Don Des Jarlais, director of the chemical dependency institute at New York City's Beth Israel Medical Center.

"But at some point, people using these drugs are going to become more aware of the dangers," he said.

Frieden said the data show a need for more prescription drug monitoring programs at the state level, and more laws shutting down "pill mills" — doctor offices and pharmacies that over-prescribe addictive medicines.

Last month, a federal panel of drug safety specialists recommended that Vicodin and dozens of other medicines be subjected to the same restrictions as other narcotic drugs like oxycodone and morphine. Meanwhile, more and more hospitals have been establishing tougher restrictions on painkiller prescriptions and refills.

One example: The University of Colorado Hospital in Aurora is considering a rule that would ban emergency doctors from prescribing more medicine for patients who say they lost their pain meds, Zane said.

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Stobbe reported from Atlanta.

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Online:

JAMA: http://www.jama.ama-assn.org

CDC: http://www.cdc.gov

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AP Medical Writer Lindsey Tanner can be reached at http://www.twitter.com

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M&A deals lift Wall Street shares nearer a record high

NEW YORK (Reuters) - U.S. stocks rose on Tuesday as this year's ongoing surge in merger activity suggested investors were still finding value in the market even as indexes closed in on all-time highs.

Office Depot Inc surged 9.4 percent to $5.02 after a person familiar with the matter said the No. 2 U.S. office supply retailer was in advanced talks to merge with smaller rival OfficeMax Inc , which jumped more than 20 percent.

News of the potential move came just days after Berkshire Hathaway and a partner agreed to acquire H.J. Heinz Co for $23 billion, and following a revised $20 billion takeover of Mexican brewer Grupo Modelo by Anheuser-Busch InBev .

Deal activity has helped equities resist a pullback as investors use dips in stocks as buying opportunities. The S&P is up about 7 percent so far in 2013 and has climbed for the past seven weeks in its longest weekly winning streak since January 2011, though most of the weekly gains have been slim.

The Dow industrials closed 0.9 percent away from their record high while S&P 500 was 2.2 percent off its peak.

"Deals are good for the market," said Frank Lesh, a futures analyst and broker at FuturePath Trading LLC in Chicago. "The fact that they're being done is a positive."

More than $158 billion in deals has been announced so far in 2013, more than double the activity in the same period last year and accounting for 57 percent of global deal volumes, according to Thomson Reuters Deals Intelligence.

The Dow Jones industrial average <.dji> gained 53.91 points, or 0.39 percent, to 14,035.67. The Standard & Poor's 500 Index <.spx> gained 11.15 points, or 0.73 percent, to 1,530.94. The Nasdaq Composite Index <.ixic> gained 21.56 points, or 0.68 percent, to 3,213.59.

Other stocks in the office supplies sector also rose. Larger rival Staples Inc shot up 13.1 percent to $14.65 as the best performer on the S&P 500.

"Equity investors have to be encouraged by M&A since, if the number crunchers are offering large premiums, that shows how much value is still in the market," said Mike Gibbs, co-head of the equity advisory group at Raymond James in Memphis, Tennessee.

On the downside, health insurance stocks tumbled, led by a 6.4 percent drop in Humana Inc to $73.01. The company said the government's proposed 2014 payment rates for Medicare Advantage participants were lower than expected and would hurt its profit outlook.

UnitedHealth Group lost 1.2 percent to $56.66. The Morgan Stanley healthcare payor index <.hmo> dropped 1.2 percent.

Wall Street's strong start to the year was fueled by better-than-expected corporate earnings, as well as a compromise in Washington that temporarily averted automatic spending cuts and tax hikes that are predicted to damage the economy.

The compromise on across-the-board spending cuts postponed the matter until March 1, at which point the cuts take effect. Ahead of the debate over the cuts, known as sequestration, further gains for stocks may be difficult to come by.

Some investors say the debate could be the catalyst for a long anticipated sell-off after the market's recent strong run.

Carter Worth, a technical analyst at Oppenheimer, pointed to the "especially complacent action of the past six weeks," noting that, as of Friday, stocks have gone 33 sessions without a dip of more than 1.5 percent.

"We would be selling aggressively into the market's current strength," he said in a research note.

Economic data showed the NAHB/Wells Fargo Housing Market index unexpectedly edged down to 46 in February from 47 in the prior month as builders faced higher material costs.

According to the Thomson Reuters data through Monday morning, of the 391 companies in the S&P 500 that have reported results, 70.1 percent have exceeded analysts' expectations, compared with a 62 percent average since 1994 and 65 percent over the past four quarters.

Fourth-quarter earnings for S&P 500 companies have risen 5.6 percent, according to the data, above a 1.9 percent forecast at the start of the earnings season.

Express Scripts rose 2.5 percent to $56.98 after the pharmacy benefits manager posted fourth-quarter earnings.

About two stocks rose for everyone that fell on the New York Stock Exchange and Nasdaq. About 6.48 billion shares changed hands on the New York Stock Exchange, the Nasdaq and NYSE MKT, in line with the daily average so far this year.

(Additional reporting by Chuck Mikolajczak Ryan Vlastelica and Rodrigo Campos; Editing by Chizu Nomiyama, Kenneth Barry and Nick Zieminski)

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Brazen Jewel Robbery at Brussels Airport Nets $50 Million in Diamonds

BRUSSELS — They arrived at Brussels Airport armed with automatic weapons and dressed in police uniforms aboard two vehicles equipped with blue police lights. But their most important weapon was information: the eight hooded gangsters who on Monday evening seized diamonds worth tens of millions of dollars from a passenger plane preparing to depart for Switzerland knew exactly when to strike — just 20 minutes before takeoff.

Forcing their way through the airport’s perimeter fence, the thieves raced, police lights flashing, to flight LX789, which had just been loaded with diamonds from a Brinks armored van from Antwerp, Belgium, and was getting ready for an 8:05 p.m. departure for Zurich.

“There is a gap of only a few minutes” between the loading of valuable cargo and the moment the plane starts to move, said Caroline De Wolf, a spokeswoman for the Antwerp World Diamond Centre, an industry body that promotes the diamond business in Belgium. “The people who did this knew there was going to be this gap and when.”

They also knew they had to move swiftly in a secure airport zone swarming with police officers and security guards. Waving guns that the Brussels prosecutors office described as “like Kalashnikovs,” they calmly ordered ground staff and the pilot, who was outside the plane making a final inspection, to back off and began unloading scores of gem-filled packets from the cargo hold. Without firing a shot, they then sped away into the night with a booty that the Antwerp Diamond Centre said was worth around $50 million but which some Belgian news media reported as worth much more.

The thieves’ only mishap: they got away with 120 packets of diamonds but left some gems behind in their rush.

“They were very, very professional,” said the Brussels prosecutor Ine Van Wymersch, who said the whole operation lasted barely five minutes. The police, she added, are now examining whether the thieves had inside information. “This is an obvious possibility,” she said.

Passengers, already on board the plane awaiting takeoff, had no idea anything was amiss until they were told to disembark as their Zurich-bound flight, operated by Helvetic Airways, had been canceled.

“I am certain this was an inside job,” said Doron Levy, an expert in airport security at a French risk management company, Ofek. The theft, he added, was “incredibly audacious and well organized,” and beyond the means of all but the most experienced and strong-nerved criminals. “In big jobs like this we are often surprised by the level of preparation and information: they know so much they probably know the employees by name.”

He said the audacity of the crime recalled in some ways the so-called Pink Panther robberies, a long series of brazen raids on high-end jewelers in Geneva, London and elsewhere blamed on criminal gangs from the Balkans. But he said the military precision of Monday’s diamond robbery and the targeting of an airport suggested a far higher level of organization than the cruder Pink Panther operations.

The police have yet to make any arrests related to the airport robbery, said the prosecutor, but have found a burned-out white van that they believe may have been used by the robbers. It was found near the airport late on Monday.

Scrambling to crack a crime that has delivered an embarrassing blow to the reputation of Brussels Airport and Antwerp’s diamond industry, the Belgian police are now looking into possible links with earlier robberies at the same airport. The airport, which handles nearly daily deliveries of diamonds to and from Antwerp, the world’s leading diamond trading center, has been targeted on three previous occasions since the mid-1990s by thieves using similar methods to seize gems and other valuables. Most of the culprits in those robberies have been caught.

Jan Van Der Cruysse, a spokesman for the airport, insisted that security was entirely up to international standards, but “what we face is organized crime with methods and means not addressed in aviation security measures as we know them today.” Precautions designed to combat would-be bombers and other threats, he added, could not prevent commando-style raids by heavily armed criminals. “This involves much more than an aviation security problem.”

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